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Article

Activated protein C: biased for translation

1 Apr 2015

Abstract excerpt

The homeostatic blood protease, activated protein C (APC), can function as (1) an antithrombotic on the basis of inactivation of clotting factors Va and VIIIa; (2) a cytoprotective on the basis of endothelial barrier stabilization and anti-inflammatory and antiapoptotic actions; and (3) a regenerative on the basis of stimulation of neurogenesis, angiogenesis, and wound healing. Pharmacologic therapies using...

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Identifiers

PMID: 25824691
DOI: 10.1182/blood-2015-02-355974

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