Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.

Stroke - 1 May 2009

Wang Yaoming, Thiyagarajan Meenakshisundaram, Chow Nienwen, Singh Itender, Guo Huang, Davis Thomas P, Zlokovic Berislav V

Abstract excerpt

BACKGROUND AND PURPOSE: Activated protein C (APC), a protease with anticoagulant and cytoprotective activities, protects neurons and endothelium from ischemic injury. Drotrecogin-alfa activated, a hyperanticoagulant form of human recombinant APC, is currently being studied in patients with ischemic stroke. How changes in APC anticoagulant activity influence APC's neuroprotection and risk for bleeding is not...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebral Hemorrhage
Share to Excitatory Amino Acid Agonists

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fibrinolytic Agents

Share to Infarction, Middle Cerebral Artery

Share to N-Acetylneuraminic Acid

Share to N-Methylaspartate

Share to Neuroprotective Agents

Share to Partial Thromboplastin Time

Source

Open in PubMed Open full text

Identifiers

PMID: 19057019
DOI: 10.1161/STROKEAHA.108.536680
PMCID: PMC2691176

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.PMID 19057019Read ↗

Neuroprotective activities of activated protein C mutant with reduced anticoagulant activity.Semantic proximity Read ↗

Species-dependent neuroprotection by activated protein C mutants with reduced anticoagulant activity.Semantic proximity Read ↗

Activated protein C: biased for translationSemantic proximity Read ↗

Neurotoxicity of the anticoagulant-selective E149A-activated protein C variant after focal ischemic stroke in mice.Semantic proximity Read ↗

Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury.Semantic proximity Read ↗

An activated protein C analog stimulates neuronal production by human neural progenitor cells via a PAR1-PAR3-S1PR1-Akt pathway.Semantic proximity Read ↗

Engineering the proteolytic specificity of activated protein C improves its pharmacological properties.Semantic proximity Read ↗

Activated protein C mutant with minimal anticoagulant activity, normal cytoprotective activity, and preservation of thrombin activable fibrinolysis inhibitor-dependent cytoprotective functions.Semantic proximity Read ↗

Protein C anticoagulant and cytoprotective pathways.Semantic proximity Read ↗

Activated protein C variants with normal cytoprotective but reduced anticoagulant activity.Semantic proximity Read ↗

Hyperantithrombotic, noncytoprotective Glu149Ala-activated protein C mutant.Semantic proximity Read ↗

Novel mechanisms for activated protein C cytoprotective activities involving noncanonical activation of protease-activated receptor 3Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.