Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Plasmodium falciparum pfmdr1 amplification, mefloquine resistance, and parasite fitness.

Antimicrobial agents and chemotherapy - 1 Apr 2009

Preechapornkul Piyanuch, Imwong Mallika, Chotivanich Kesinee, Pongtavornpinyo Wirichada, Dondorp Arjen M, Day Nicholas P J, White Nicholas J, Pukrittayakamee Sasithon

Abstract excerpt

Mefloquine is widely used in combination with artemisinin derivatives for the treatment of falciparum malaria. Mefloquine resistance in Plasmodium falciparum has been related to increased copy numbers of multidrug-resistant gene 1 (pfmdr1). We studied the ex vivo dynamics of pfmdr1 gene amplification in culture-adapted P. falciparum in relation to mefloquine resistance and parasite fitness. A Thai P. falciparum...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimalarials
Share to Gene Amplification

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Dosage

Share to Genotype

Share to Malaria, Falciparum

Share to Mefloquine

Share to Multidrug Resistance-Associated Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19164150
DOI: 10.1128/AAC.00241-08
PMCID: PMC2663078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Plasmodium falciparum pfmdr1 amplification, mefloquine resistance, and parasite fitness.PMID 19164150Read ↗

Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number.Semantic proximity Read ↗

Role of pfmdr1 amplification and expression in induction of resistance to artemisinin derivatives in Plasmodium falciparum.Semantic proximity Read ↗

Amplification of pfmdr1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from ThailandSemantic proximity Read ↗

Association Between the pfmdr1 Gene and In Vitro Artemether and Lumefantrine Sensitivity in Thai Isolates of Plasmodium falciparumSemantic proximity Read ↗

Amplification of pvmdr1 associated with multidrug-resistant Plasmodium vivax.Semantic proximity Read ↗

pfmdr1 genotyping and in vivo mefloquine resistance on the Thai-Myanmar border.Semantic proximity Read ↗

Plasmodium falciparum isolates with increased pfmdr1 copy number circulate in West Africa.Semantic proximity Read ↗

Multiple genetic backgrounds of the amplified Plasmodium falciparum multidrug resistance (pfmdr1) gene and selective sweep of 184F mutation in Cambodia.Semantic proximity Read ↗

Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum.Semantic proximity Read ↗

Fitness of artemisinin-resistant Plasmodium falciparum in vitro.Semantic proximity Read ↗

Amplification of<i>Plasmodium falciparum</i>Multidrug Resistance Gene 1 in Isolates from GabonSemantic proximity Read ↗

Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.