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Article

Plasmodium falciparum isolates with increased pfmdr1 copy number circulate in West Africa.

Antimicrobial agents and chemotherapy - 1 Jul 2010

Witkowski Benoit, Nicolau Marie-Laure, Soh Patrice Njomnang, Iriart Xavier, Menard Sandie, Alvarez Muriel, Marchou Bruno, Magnaval Jean-François, Benoit-Vical Françoise, Berry Antoine

Abstract excerpt

Amplification of pfmdr1 in Plasmodium falciparum is linked to resistance to aryl-amino-alcohols and in reduced susceptibility to artemisinins. We demonstrate here that duplicated pfmdr1 genotypes circulate in West Africa. The monitoring of this prevalence in Africa appears essential for determining the antimalarial policy and to maintain the efficiency of artemisinin-based combination therapy (ACT) for as long as...

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Identifiers

PMID: 20404118
DOI: 10.1128/AAC.00209-10
PMCID: PMC2897320

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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