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Article

Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number.

Lancet (London, England) - 1 Jan 2000

Price Ric N, Uhlemann Anne-Catrin, Brockman Alan, McGready Rose, Ashley Elizabeth, Phaipun Lucy, Patel Rina, Laing Kenneth, Looareesuwan Sornchai, White Nicholas J, Nosten François, Krishna Sanjeev

Abstract excerpt

BACKGROUND: The borders of Thailand harbour the world's most multidrug resistant Plasmodium falciparum parasites. In 1984 mefloquine was introduced as treatment for uncomplicated falciparum malaria, but substantial resistance developed within 6 years. A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are...

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Identifiers

PMID: 15288742
DOI: 10.1016/S0140-6736(04)16767-6
PMCID: PMC4337987

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