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Article

pfmdr1 genotyping and in vivo mefloquine resistance on the Thai-Myanmar border.

The American journal of tropical medicine and hygiene - 1 May 2005

Nelson Amy L, Purfield Anne, McDaniel Philip, Uthaimongkol Nichipat, Buathong Nillawan, Sriwichai Sabaitip, Miller R Scott, Wongsrichanalai Chansuda, Meshnick Steven R

Abstract excerpt

Molecular markers have been proposed as a method of monitoring malaria drug resistance and could potentially be used to prolong the life span of antimalarial drugs. Single nucleotide polymorphisms (SNPs) in the Plasmodium falciparum gene pfmdr1 and increased gene copy number have been associated with in vitro drug resistance but have not been well studied in vivo. In a prospective cohort study of malaria patients...

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PMID: 15891133

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