Article
Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand.
The Journal of infectious diseases - 1 Jan 2007
Uhlemann Anne-Catrin, McGready Rose, Ashley Elizabeth A, Brockman Alan, Singhasivanon Pratap, Krishna Sanjeev, White Nicholas J, Nosten Francois, Price Ric N
Abstract excerpt
BACKGROUND: Increased pfmdr1 copy number is associated with reduced susceptibility to structurally unrelated antimalarial drugs. We assessed how administration of different antimalarial drugs altered pfmdr1 polymorphism in parasites from patients who experienced treatment failure. METHODS: In studies conducted on the northwestern border of Thailand, amplifications and single-nucleotide polymorphisms in pfmdr1...
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