Article
Multiple genetic backgrounds of the amplified Plasmodium falciparum multidrug resistance (pfmdr1) gene and selective sweep of 184F mutation in Cambodia.
The Journal of infectious diseases - 15 May 2010
Vinayak Sumiti, Alam Md Tauqeer, Sem Rithy, Shah Naman K, Susanti Augustina I, Lim Pharath, Muth Sinuon, Maguire Jason D, Rogers William O, Fandeur Thierry, Barnwell John W, Escalante Ananias A, Wongsrichanalai Chansuda, Ariey Frederick, Meshnick Steven R, Udhayakumar Venkatachalam
Abstract excerpt
BACKGROUND: The emergence of artesunate-mefloquine (AS+MQ)-resistant Plasmodium falciparum in the Thailand-Cambodia region is a major concern for malaria control. Studies indicate that copy number increase and key alleles in the pfmdr1 gene are associated with AS+MQ resistance. In the present study, we investigated evidence for a selective sweep around pfmdr1 because of the spread of adaptive mutation and/or...
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