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Article

Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum.

Malaria journal - 30 Jun 2021

Duvalsaint Marvin, Conrad Melissa D, Tukwasibwe Stephen, Tumwebaze Patrick K, Legac Jennifer, Cooper Roland A, Rosenthal Philip J

Abstract excerpt

BACKGROUND: Anti-malarial drug resistance may be limited by decreased fitness in resistant parasites. Important contributors to resistance are mutations in the Plasmodium falciparum putative drug transporter PfMDR1. METHODS: Impacts on in vitro fitness of two common PfMDR1 polymorphisms, N86Y, which is associated with sensitivity to multiple drugs, and Y184F, which has no clear impact on drug sensitivity, were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34193148
DOI: 10.1186/s12936-021-03823-x
PMCID: PMC8247092

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