Article
Amplification of pvmdr1 associated with multidrug-resistant Plasmodium vivax.
The Journal of infectious diseases - 15 Nov 2008
Suwanarusk R, Chavchich M, Russell B, Jaidee A, Chalfein F, Barends M, Prasetyorini B, Kenangalem E, Piera K A, Lek-Uthai U, Anstey N M, Tjitra E, Nosten F, Cheng Q, Price R N
Abstract excerpt
BACKGROUND: Multidrug-resistant strains of Plasmodium vivax are emerging in Southeast Asia. METHODS: In vitro drug susceptibility and pvmdr1 genotype were determined in P. vivax field isolates from Indonesia and Thailand. RESULTS: Increased pvmdr1 copy number was present in 21% of isolates from Thailand (15/71) and none from Indonesia (0/114; P < .001). Compared with Indonesian isolates, the median IC(50) of Thai...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antimalarials
- Drug Resistance, Multiple
- Gene Dosage
- Genotype
- Inhibitory Concentration 50
- Malaria, Vivax
- Parasitic Sensitivity Tests