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Article

Genetic and other factors determining mannose-binding lectin levels in American Indians: the Strong Heart Study.

BMC medical genetics - 22 Jan 2009

Best Lyle G, Ferrell Robert E, Decroo Susan, North Kari E, Maccluer Jean W, Zhang Ying, Lee Elisa T, Howard Barbara V, Umans Jason, Palmieri Vittorio, Garred Peter

Abstract excerpt

BACKGROUND: Mannose-binding lectin (MBL) forms an integral part of the innate immune system. Persistent, subclinical infections and chronic inflammatory states are hypothesized to contribute to the pathogenesis of atherosclerosis. MBL gene (MBL2) variants with between 12 to 25% allele frequency in Caucasian and other populations, result in markedly reduced expression of functional protein. Prospective...

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Source

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Identifiers

PMID: 19161617
DOI: 10.1186/1471-2350-10-5
PMCID: PMC2637849

Genes

MBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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