Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish.

Diabetes - 1 Aug 2010

Muller Yunhua L, Hanson Robert L, Bian Li, Mack Janel, Shi Xiaolian, Pakyz Ruth, Shuldiner Alan R, Knowler William C, Bogardus Clifton, Baier Leslie J

Abstract excerpt

OBJECTIVE: MBL2 encodes the mannose-binding lectin, which is a key player in the innate immune system and has recently been found to play a role in insulin resistance and development of type 1 diabetes and gestational diabetes mellitus. To assess the role of MBL2 in diabetes susceptibility, this gene was analyzed in the Pima Indian population, which has a high prevalence of type 2 diabetes. RESEARCH DESIGN AND...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to Glucose Tolerance Test

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Indians, North American

Share to Mannose-Binding Lectin

Share to Prediabetic State

Share to Promoter Regions, Genetic

Share to Risk Assessment

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 20522590
DOI: 10.2337/db09-1593
PMCID: PMC2911048

Genes

MBL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional variants in MBL2 are associated with type 2 diabetes and pre-diabetes traits in Pima Indians and the old order Amish.PMID 20522590Read ↗

Genetic and other factors determining mannose-binding lectin levels in American Indians: the Strong Heart Study.Semantic proximity Read ↗

Analysis of type 2 diabetes and obesity genetic variants in Mexican Pima Indians: Marked allelic differentiation among Amerindians at HLA.Semantic proximity Read ↗

Identification of novel candidate genes for type 2 diabetes from a genome-wide association scan in the Old Order Amish: evidence for replication from diabetes-related quantitative traits and from independent populations.Semantic proximity Read ↗

MBL2 variations and malaria susceptibility in Indian populations.Semantic proximity Read ↗

Sequence analysis of the mannose-binding lectin (MBL2) gene reveals a high degree of heterozygosity with evidence of selection.Semantic proximity Read ↗

Association of levels of mannose-binding lectin and the MBL2 gene with type 2 diabetes and diabetic nephropathy.Semantic proximity Read ↗

[Association between mannose-binding-lectin gene and type 2 diabetic patients in Chinese population living in the northern areas of China].Semantic proximity Read ↗

Mannose-binding lectin and its genetic variants.Semantic proximity Read ↗

Common variants of SLAMF1 and ITLN1 on 1q21 are associated with type 2 diabetes in Indian population.Semantic proximity Read ↗

High MBL-expressing genotypes are associated with deterioration in renal function in type 2 diabetes.Semantic proximity Read ↗

A two-nucleotide deletion renders the mannose-binding lectin 2 (MBL2) gene nonfunctional in Danish Landrace and Duroc pigs.Semantic proximity Read ↗

Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.