Article
If there is an evolutionary selection pressure for the high frequency of MBL2 polymorphisms, what is it?
Clinical and experimental immunology - 1 May 2014
Eisen D P, Osthoff M
Abstract excerpt
Either immune selection or stochastic processes may have influenced the frequency of highly polymorphic genes such as mannose-binding lectin 2 (MBL2). This pattern recognition receptor of the innate immune system recognizes and binds to pathogenic microorganisms and apoptotic cells leading to lectin pathway complement killing or clearance. In almost all of a large number of studies in different ethnic groups...
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