Article
Mannose-binding lectin genetics: from A to Z.
Biochemical Society transactions - 1 Dec 2008
Garred Peter
Abstract excerpt
MBL (mannose-binding lectin) is primarily a liver-derived collagen-like serum protein. It binds sugar structures on micro-organisms and on dying host cells and is one of the four known mediators that initiate activation of the complement system via the lectin pathway. Common variant alleles situated both in promoter and structural regions of the human MBL gene (MBL2) influence the stability and the serum...
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