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Article

Identification of multidrug and toxin extrusion (MATE1 and MATE2-K) variants with complete loss of transport activity.

Journal of human genetics - 1 Jan 2009

Kajiwara Moto, Terada Tomohiro, Ogasawara Ken, Iwano Junko, Katsura Toshiya, Fukatsu Atsushi, Doi Toshio, Inui Ken-ichi

Abstract excerpt

H(+)/organic cation antiporters (multidrug and toxin extrusion: MATE1 and MATE2-K) play important roles in the renal tubular secretion of cationic drugs. We have recently identified a regulatory single nucleotide polymorphism (SNP) of the MATE1 gene (-32G>A). There is no other information about SNPs of the MATE gene. In this study, we evaluated the functional significance of genetic polymorphisms in MATE1 and...

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Identifiers

PMID: 19158817
DOI: 10.1038/jhg.2008.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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