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Multidrug and toxin extrusion proteins as transporters of antimicrobial drugs.

Expert opinion on drug metabolism & toxicology - 1 Dec 2012

Nies Anne T, Damme Katja, Schaeffeler Elke, Schwab Matthias

Abstract excerpt

INTRODUCTION: Antimicrobial drugs are essential in the treatment of infectious diseases. A better understanding of transport processes involved in drug disposition will improve the predictability of drug-drug interactions with consequences for drug response. Multidrug And Toxin Extrusion (MATE; SLC47A) proteins are efflux transporters mediating the excretion of several antimicrobial drugs as well as other organic...

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PMID: 22970772
DOI: 10.1517/17425255.2012.722996

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