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Article

Kinesin-5-dependent poleward flux and spindle length control in Drosophila embryo mitosis.

Molecular biology of the cell - 1 Mar 2009

Brust-Mascher Ingrid, Sommi Patrizia, Cheerambathur Dhanya K, Scholey Jonathan M

Abstract excerpt

We used antibody microinjection and genetic manipulations to dissect the various roles of the homotetrameric kinesin-5, KLP61F, in astral, centrosome-controlled Drosophila embryo spindles and to test the hypothesis that it slides apart interpolar (ip) microtubules (MT), thereby controlling poleward flux and spindle length. In wild-type and Ncd null mutant embryos, anti-KLP61F dissociated the motor from spindles,...

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Identifiers

PMID: 19158379
DOI: 10.1091/mbc.e08-10-1033
PMCID: PMC2655252

Genes

NEB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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