Article
Microtubule-sliding activity of a kinesin-8 promotes spindle assembly and spindle-length control.
Nature cell biology - 1 Aug 2013
Su Xiaolei, Arellano-Santoyo Hugo, Portran Didier, Gaillard Jeremie, Vantard Marylin, Thery Manuel, Pellman David
Abstract excerpt
Molecular motors play critical roles in the formation of mitotic spindles, either through controlling the stability of individual microtubules, or by crosslinking and sliding microtubule arrays. Kinesin-8 motors are best known for their regulatory roles in controlling microtubule dynamics. They contain microtubule-destabilizing activities, and restrict spindle length in a wide variety of cell types and organisms....
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