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Article

Kinetochore dynein generates a poleward pulling force to facilitate congression and full chromosome alignment.

Cell research - 1 Aug 2007

Li Yan, Yu Wei, Liang Yun, Zhu Xueliang

Abstract excerpt

For proper chromosome segregation, all kinetochores must achieve bipolar microtubule (MT) attachment and subsequently align at the spindle equator before anaphase onset. The MT minus end-directed motor dynein/dynactin binds kinetochores in prometaphase and has long been implicated in chromosome congression. Unfortunately, inactivation of dynein usually disturbs spindle organization, thus hampering evaluation of...

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Source

Identifiers

PMID: 17680027
DOI: 10.1038/cr.2007.65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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