Article

MNT loss in MYC-driven B lymphoma cells enhances apoptosis, inhibits proliferation and increases sensitivity to cancer drugs

2026-05-01

Abstract excerpt

<h4>ABSTRACT</h4> Our previous mouse genetic studies showed that loss of the transcription repressor MNT enhanced apoptosis of premalignant lymphoid cells over-expressing MYC and inhibited lymphoma development. Here, we have explored the consequences of inducing Mnt deletion in fully malignant lymphoma cells. MNT loss provoked apoptosis of p53 wt and, albeit more slowly, p53 mutant Eμ-Myc lymphoma cells, prec...

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Literature Corpus work: d2234735-273a-585d-9eb9-c964fa671888
DOI: 10.64898/2026.04.29.721758

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