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Article

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression.

Oncogene - 12 Jul 2012

Mérino D, Strasser A, Bouillet P

Abstract excerpt

Overexpression of the transcriptional regulator Myc is thought to be the cause or a contributing factor in the development of a large number of human lymphomas and certain other cancers. Apoptotic cell death constitutes a tumor suppressive mechanism, particularly in the context of Myc overexpression. Accordingly, lymphoma development in Eμ-Myc transgenic mice, which mimic the Myc/IgH chromosomal translocation...

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Source

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Identifiers

PMID: 22081075
DOI: 10.1038/onc.2011.508
PMCID: PMC3361534

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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