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Article

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis.

Cell reports - 15 Mar 2016

Grabow Stephanie, Delbridge Alex R D, Aubrey Brandon J, Vandenberg Cassandra J, Strasser Andreas

Abstract excerpt

MCL-1 is critical for progenitor cell survival during emergency hematopoiesis, but its role in sustaining cells undergoing transformation and in lymphomagenesis is only poorly understood. We investigated the importance of MCL-1 in the survival of B lymphoid progenitors undergoing MYC-driven transformation and its functional interactions with pro-apoptotic BIM and PUMA and the tumor suppressor p53 in lymphoma...

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Share to Apoptosis Regulatory Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26947081
DOI: 10.1016/j.celrep.2016.02.039

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis.PMID 26947081Read ↗

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Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.Semantic proximity Read ↗

Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation.Semantic proximity Read ↗

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Antagonism between MCL-1 and PUMA governs stem/progenitor cell survival during hematopoietic recovery from stressSemantic proximity Read ↗

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression.Semantic proximity Read ↗

Loss of MYSM1 deubiquitinase catalytic activity protects against MYC-driven B cell lymphoma via tumor intrinsic effects and indirect modulation of antitumor immunitySemantic proximity Read ↗

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