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Article

BIM Is the Primary Mediator of MYC-Induced Apoptosis in Multiple Solid Tissues

28 Aug 2014

Abstract excerpt

MYC is one of the most frequently overexpressed oncogenes in human cancer, and even modestly deregulated MYC can initiate ectopic proliferation in many postmitotic cell types in vivo. Sensitization of cells to apoptosis limits MYC's oncogenic potential. However, the mechanism through which MYC induces apoptosis is controversial. Some studies implicate p19ARF-mediated stabilization of p53, followed by induction of...

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PMID: 25176652
DOI: 10.1016/j.celrep.2014.07.057

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