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Article

Selection against <i>PUMA</i> Gene Expression in Myc-Driven B-Cell Lymphomagenesis

24 Jun 2008

Abstract excerpt

The p53 tumor suppressor pathway limits oncogenesis by inducing cell cycle arrest or apoptosis. A key p53 target gene is PUMA, which encodes a BH3-only proapoptotic protein. Here we demonstrate that Puma deletion in the Emu-Myc mouse model of Burkitt lymphoma accelerates lymphomagenesis and that approximately 75% of Emu-Myc lymphomas naturally select against Puma protein expression. Furthermore, approximately 40%...

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PMID: 18573879
DOI: 10.1128/mcb.00907-07

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Selection against <i>PUMA</i> Gene Expression in Myc-Driven B-Cell LymphomagenesisPMID 18573879Read ↗

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