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Article

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.

Nature - 11 Aug 2005

Hemann Michael T, Bric Anka, Teruya-Feldstein Julie, Herbst Andreas, Nilsson Jonas A, Cordon-Cardo Carlos, Cleveland John L, Tansey William P, Lowe Scott W

Abstract excerpt

The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report that two common mutant MYC alleles derived from human Burkitt's lymphoma uncouple proliferation from apoptosis and, as a result, are more effective than wild-type MYC at promoting B cell lymphomagenesis in mice. Mutant MYC proteins retain...

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Share to Adoptive Transfer
Share to Bcl-2-Like Protein 11

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Cyclin-Dependent Kinase Inhibitor p21

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Share to Proto-Oncogene Proteins c-myc

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Share to Tumor Suppressor Protein p14ARF

Source

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Identifiers

PMID: 16094360
DOI: 10.1038/nature03845
PMCID: PMC4599579

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants.PMID 16094360Read ↗

Targeting of MCL-1 kills MYC-driven mouse and human lymphomas even when they bear mutations in p53.Semantic proximity Read ↗

Bim must be able to engage all pro-survival Bcl-2 family members for efficient tumor suppression.Semantic proximity Read ↗

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis.Semantic proximity Read ↗

Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.Semantic proximity Read ↗

MNT loss in MYC-driven B lymphoma cells enhances apoptosis, inhibits proliferation and increases sensitivity to cancer drugsSemantic proximity Read ↗

Dissecting p53 tumor suppressor functions in vivo.Semantic proximity Read ↗

The great MYC escape in tumorigenesis.Semantic proximity Read ↗

p53 status dictates responses of B lymphomas to monotherapy with proteasome inhibitors.Semantic proximity Read ↗

The IKK2/NF-κB pathway suppresses MYC-induced lymphomagenesisSemantic proximity Read ↗

Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugsSemantic proximity Read ↗

Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis.Semantic proximity Read ↗

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2.Semantic proximity Read ↗

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