Article
Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium.
American journal of human genetics - 1 Mar 1998
Ford D, Easton D F, Stratton M, Narod S, Goldgar D, Devilee P, Bishop D T, Weber B, Lenoir G, Chang-Claude J, Sobol H, Teare M D, Struewing J, Arason A, Scherneck S, Peto J, Rebbeck T R, Tonin P, Neuhausen S, Barkardottir R, Eyfjord J, Lynch H, Ponder B A, Gayther S A, Zelada-Hedman M
Abstract excerpt
The contribution of BRCA1 and BRCA2 to inherited breast cancer was assessed by linkage and mutation analysis in 237 families, each with at least four cases of breast cancer, collected by the Breast Cancer Linkage Consortium. Families were included without regard to the occurrence of ovarian or other cancers. Overall, disease was linked to BRCA1 in an estimated 52% of families, to BRCA2 in 32% of families, and to...
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