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Article

LRRK2 and neurodegeneration.

Acta neuropathologica - 1 Mar 2009

Santpere Gabriel, Ferrer Isidre

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 gene (PARK8/LRRK2) encoding the protein Lrrk2 are causative of inherited and sporadic Parkinson's disease (PD) with phenotypic manifestations of frontotemporal lobar degeneration, corticobasal degeneration and associated motor neuron disease in some patients, and with variable penetrance. Neuropathology is characterized by loss of dopaminergic neurons in the substantia...

Topics

Alzheimer Disease
Animals
Antibody Specificity
Brain
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mutation
Nerve Degeneration
Neurodegenerative Diseases
Parkinson Disease
Protein Serine-Threonine Kinases

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Identifiers

PMID: 19142648
DOI: 10.1007/s00401-008-0478-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19142648-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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