Article
LRRK2 and neurodegeneration.
Acta neuropathologica - 1 Mar 2009
Santpere Gabriel, Ferrer Isidre
Abstract excerpt
Mutations in leucine-rich repeat kinase 2 gene (PARK8/LRRK2) encoding the protein Lrrk2 are causative of inherited and sporadic Parkinson's disease (PD) with phenotypic manifestations of frontotemporal lobar degeneration, corticobasal degeneration and associated motor neuron disease in some patients, and with variable penetrance. Neuropathology is characterized by loss of dopaminergic neurons in the substantia...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.