Biochemical and pathological characterization of Lrrk2.

doi:10.1002/ana.20791

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Article

Biochemical and pathological characterization of Lrrk2.

Annals of neurology - 1 Feb 2006

Giasson Benoit I, Covy Jason P, Bonini Nancy M, Hurtig Howard I, Farrer Matthew J, Trojanowski John Q, Van Deerlin Vivianna M

Abstract excerpt

OBJECTIVE: Mutations in leucine-rich repeat kinase 2 (LRRK2) recently have been identified as the most common genetic cause of late-onset sporadic and familial Parkinson's disease (PD). The studies herein explore the biological and pathological properties of Lrrk2. METHODS: Genetic analysis was p...

Topics

Adult
Aged
Aged, 80 and over
Amino Acid Sequence
Animals
Blotting, Western
Brain
Cell Line
DNA Mutational Analysis
Female
Genetic Predisposition to Disease
Glycine
Humans
Immunohistochemistry
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Male
Mice
Middle Aged

Source

Open in PubMed

Identifiers

PMID: 16437584
DOI: 10.1002/ana.20791

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-16437584-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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