Article
Biochemical and pathological characterization of Lrrk2.
Annals of neurology - 1 Feb 2006
Giasson Benoit I, Covy Jason P, Bonini Nancy M, Hurtig Howard I, Farrer Matthew J, Trojanowski John Q, Van Deerlin Vivianna M
Abstract excerpt
OBJECTIVE: Mutations in leucine-rich repeat kinase 2 (LRRK2) recently have been identified as the most common genetic cause of late-onset sporadic and familial Parkinson's disease (PD). The studies herein explore the biological and pathological properties of Lrrk2. METHODS: Genetic analysis was performed to identify autopsied patients with the most common Lrrk2 mutation (G2019S). Using an antibody specific to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.