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Article

Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2.

The FEBS journal - 1 Dec 2008

Devine Michael J, Lewis Patrick A

Abstract excerpt

The last decade has seen clear links emerge between the genetic determinants and neuropathological hallmarks of parkinsonism and dementia, notably with the discovery of mutations in alpha-synuclein and tau. Following the description of mutations in LRRK2 linked to Parkinson's disease, characterized by variable pathology including either alpha-synuclein or tau deposition, it has been suggested that LRRK2 functions...

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Source

Identifiers

PMID: 19021752
DOI: 10.1111/j.1742-4658.2008.06707.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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