Article
Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain.
Brain research - 25 Jun 2007
Higashi Shinji, Biskup Saskia, West Andrew B, Trinkaus Daniel, Dawson Valina L, Faull Richard L M, Waldvogel Henry J, Arai Heii, Dawson Ted M, Moore Darren J, Emson Piers C
Abstract excerpt
Mutations in the LRRK2 gene cause autosomal dominant, late-onset parkinsonism, which presents with pleomorphic pathology including alpha-synucleopathy. To promote our understanding of the biological role of LRRK2 in the brain we examined the distribution of LRRK2 mRNA and protein in postmortem human brain tissue from normal and neuropathological subjects. In situ hybridization and immunohistochemical analysis...
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