Article
LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons.
Journal of Parkinson's disease - 1 Jan 2021
Henderson Michael X, Changolkar Lakshmi, Trojanowski John Q, Lee Virginia M Y
Abstract excerpt
BACKGROUND: Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease (PD) and are also associated with genetic risk in idiopathic PD. Mutations in LRRK2, including the most common p.G2019S lead to elevated kinase activity, making LRRK2 kinase inhibitors prime targets for therapeutic development. However, the role of LRRK2 kinase activity in PD pathogenesis has...
Topics
- Animals
- Brain
- Humans
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Lewy Bodies
- Mutation
- Neurons
- Parkinson Disease