Article
Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response.
The Journal of clinical investigation - 1 Feb 2009
Dazert Eva, Neumann-Haefelin Christoph, Bressanelli Stéphane, Fitzmaurice Karen, Kort Julia, Timm Jörg, McKiernan Susan, Kelleher Dermot, Gruener Norbert, Tavis John E, Rosen Hugo R, Shaw Jaqueline, Bowness Paul, Blum Hubert E, Klenerman Paul, Bartenschlager Ralf, Thimme Robert
Abstract excerpt
There is an association between expression of the MHC class I molecule HLA-B27 and protection following human infection with either HIV or HCV. In both cases, protection has been linked to HLA-B27 presentation of a single immunodominant viral peptide epitope to CD8+ T cells. If HIV mutates the HLA-B27-binding anchor of this epitope to escape the protective immune response, the result is a less-fit virus that...
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