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Article

Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2008

Wölfl Matthias, Rutebemberwa Alleluiah, Mosbruger Timothy, Mao Qing, Li Hong-mei, Netski Dale, Ray Stuart C, Pardoll Drew, Sidney John, Sette Alessandro, Allen Todd, Kuntzen Thomas, Kavanagh Daniel G, Kuball Jürgen, Greenberg Philip D, Cox Andrea L

Abstract excerpt

Hepatitis C virus (HCV) infection frequently persists despite eliciting substantial virus-specific immune responses. Thus, HCV infection provides a setting in which to investigate mechanisms of immune escape that allow for viral persistence. Viral amino acid substitutions resulting in decreased MHC binding or impaired Ag processing of T cell epitopes reduce Ag density on the cell surface, permitting evasion of T...

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Share to Epitopes, T-Lymphocyte
Share to Acute Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antigen Presentation

Share to CD8-Positive T-Lymphocytes

Share to Cell Line, Transformed

Share to Hepatitis C

Share to Receptors, Antigen, T-Cell

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Source

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Identifiers

PMID: 18941234
DOI: 10.4049/jimmunol.181.9.6435
PMCID: PMC2742502

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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