Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 mutants that escape the cytotoxic T-lymphocytes are defective in viral DNA integration

1 May 2022

Abstract excerpt

HIV-1 replication is durably controlled without antiretroviral therapy (ART) in certain infected individuals called elite controllers (ECs). These individuals express specific human leukocyte antigens (HLA) that tag HIV-infected cells for elimination by presenting viral epitopes to CD8+ cytotoxic T-lymphocytes (CTL). In HIV-infected individuals expressing HLA-B27, CTLs primarily target the viral capsid protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35719891
DOI: 10.1093/pnasnexus/pgac064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 mutants that escape the cytotoxic T-lymphocytes are defective in viral DNA integrationPMID 35719891Read ↗

HIV-1 Mutants that Escape the Cytotoxic T-Lymphocytes are Defective in Viral DNA IntegrationSemantic proximity Read ↗

Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.Semantic proximity Read ↗

Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.Semantic proximity Read ↗

HIV: current opinion in escapology.Semantic proximity Read ↗

Rapid HIV-1 Disease Progression in Individuals Infected with a Virus Adapted to Its Host Population.Semantic proximity Read ↗

Triple bypass: complicated paths to HIV escape.Semantic proximity Read ↗

HIV-1 capsid and viral DNA integrationSemantic proximity Read ↗

The presence of the Trim5alpha escape mutation H87Q in the capsid of late stage HIV-1 variants is preceded by a prolonged asymptomatic infection phase.Semantic proximity Read ↗

Structural and functional constraints limit options for cytotoxic T-lymphocyte escape in the immunodominant HLA-B27-restricted epitope in human immunodeficiency virus type 1 capsid.Semantic proximity Read ↗

Extreme genetic fragility of the HIV-1 capsid.Semantic proximity Read ↗

Maintenance of viral suppression in HIV-1-infected HLA-B*57+ elite suppressors despite CTL escape mutations.Semantic proximity Read ↗

[Control of HIV infection and selection/ accumulation of HIV escape mutants by HIV-specific cytotoxic T lymphocytes (CTLs)].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.