Article
Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes.
Gastroenterology - 1 Feb 2011
Kim Arthur Y, Kuntzen Thomas, Timm Joerg, Nolan Brian E, Baca Melanie A, Reyor Laura L, Berical Andrew C, Feller Andrea J, Johnson Kristin L, Schulze zur Wiesch Julian, Robbins Gregory K, Chung Raymond T, Walker Bruce D, Carrington Mary, Allen Todd M, Lauer Georg M
Abstract excerpt
BACKGROUND & AIMS: HLA class I alleles are linked to spontaneous control of hepatitis C virus (HCV) and human immunodeficiency virus-1, but for HCV the roles of particular alleles and corresponding CD8(+) T-cell responses remain incompletely defined. We aimed to determine the correlations between these alleles and natural outcomes of HCV and determine associated key T-cell responses. METHODS: In a cohort of HCV...
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