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Article

Stable cytotoxic T cell escape mutation in hepatitis C virus is linked to maintenance of viral fitness.

PLoS pathogens - 5 Sept 2008

Uebelhoer Luke, Han Jin-Hwan, Callendret Benoit, Mateu Guaniri, Shoukry Naglaa H, Hanson Holly L, Rice Charles M, Walker Christopher M, Grakoui Arash

Abstract excerpt

Mechanisms by which hepatitis C virus (HCV) evades cellular immunity to establish persistence in chronically infected individuals are not clear. Mutations in human leukocyte antigen (HLA) class I-restricted epitopes targeted by CD8(+) T cells are associated with persistence, but the extent to which these mutations affect viral fitness is not fully understood. Previous work showed that the HCV quasispecies in a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18773115
DOI: 10.1371/journal.ppat.1000143
PMCID: PMC2518852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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