Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8+ T Cells.

doi:10.1128/JVI.01891-17

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Article

Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8+ T Cells.

Journal of virology - 1 Jul 2018

Karimzadeh Hadi, Kiraithe Muthamia M, Kosinska Anna D, Glaser Manuel, Fiedler Melanie, Oberhardt Valerie, Salimi Alizei Elahe, Hofmann Maike, Mok Juk Yee, Nguyen Melanie, van Esch Wim J E, Budeus Bettina, Grabowski Jan, Homs Maria, Olivero Antonella, Keyvani Hossein, Rodríguez-Frías Francisco, Tabernero David, Buti Maria, Heinold Andreas, Alavian Seyed Moayed, Bauer Tanja, Schulze Zur Wiesch Julian, Raziorrouh Bijan, Hoffmann Daniel, Smedile Antonina, Rizzetto Mario, Wedemeyer Heiner, Timm Jörg, Antes Iris, Neumann-Haefelin Christoph, Protzer Ulrike, Roggendorf Michael

Abstract excerpt

Virus-specific CD8 T cell response seems to play a significant role in the outcome of hepatitis delta virus (HDV) infection. However, the HDV-specific T cell epitope repertoire and mechanisms of CD8 T cell failure in HDV infection have been poorly characterized. We therefore aimed to characterize HDV-specific CD8 T cell epitopes and the impacts of viral mutations on immune escape. In this study, we predicted...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29669837
DOI: 10.1128/JVI.01891-17
PMCID: PMC6002722

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Source receipt: pubmed, retrieved 7 Sept 2026.

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