Article
Diffusion tensor imaging in sporadic and familial (D90A SOD1) forms of amyotrophic lateral sclerosis.
Archives of neurology - 1 Jan 2009
Stanton Biba R, Shinhmar Daisy, Turner Martin R, Williams Victoria C, Williams Steven C R, Blain Camilla R V, Giampietro Vincent P, Catani Marco, Leigh P Nigel, Andersen Peter M, Simmons Andrew
Abstract excerpt
BACKGROUND: The basis of heterogeneity in the clinical presentation and rate of progression of amyotrophic lateral sclerosis (ALS) is poorly understood. OBJECTIVES: To use diffusion tensor imaging as a measure of axonal pathologic features in vivo in ALS and to compare a homogeneous form of familial ALS (homozygous D90A SOD1 [superoxide dismutase 1]) with sporadic ALS. DESIGN: Cross-sectional diffusion tensor...
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