Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 Dec 2007

Turner Martin R, Hammers Alexander, Allsop Joanna, Al-Chalabi Ammar, Shaw Christopher E, Brooks David J, Leigh P Nigel, Andersen Peter M

Abstract excerpt

Patients homozygous for the D90A mutation of the SOD1 gene (homD90A) demonstrate markedly slower progression of disease than those patients with sporadic ALS (SALS). PET studies have demonstrated a different cortical vulnerability in the two groups, reflected also in neurophysiological studies showing reduced cortical excitability in homD90A. Voxel-based morphometric analysis of magnetic resonance images (MRIs)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Atrophy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cerebral Cortex

Share to Frontal Lobe

Share to Homozygote

Share to Magnetic Resonance Imaging

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Source

Identifiers

PMID: 18033592
DOI: 10.1080/17482960701538734

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Volumetric cortical loss in sporadic and familial amyotrophic lateral sclerosis.PMID 18033592Read ↗

Implications of structural and functional brain changes in amyotrophic lateral sclerosis.Semantic proximity Read ↗

Abnormal cortical excitability in sporadic but not homozygous D90A SOD1 ALS.Semantic proximity Read ↗

Grey matter correlates of clinical variables in amyotrophic lateral sclerosis (ALS): a neuroimaging study of ALS motor phenotype heterogeneity and cortical focality.Semantic proximity Read ↗

Distinct cerebral lesions in sporadic and 'D90A' SOD1 ALS: studies with [11C]flumazenil PET.Semantic proximity Read ↗

Differential corticospinal tract degeneration in homozygous 'D90A' SOD-1 ALS and sporadic ALS.Semantic proximity Read ↗

Brainstem–cortex disconnection in amyotrophic lateral sclerosis: bulbar impairment, genotype associations, asymptomatic changes and biomarker opportunitiesSemantic proximity Read ↗

Presymptomatic grey matter alterations in ALS kindreds: a computational neuroimaging study of asymptomatic C9orf72 and SOD1 mutation carriers.Semantic proximity Read ↗

Amyotrophic lateral sclerosis with SOD1 mutations shows distinct brain metabolic changes.Semantic proximity Read ↗

Quantitative susceptibility mapping for investigating brain iron deposits in amyotrophic lateral sclerosis: correlations with clinical phenotype and disease progression.Semantic proximity Read ↗

Corticomotoneuronal dysfunction in ALS patients with different SOD1 mutations.Semantic proximity Read ↗

Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk.Semantic proximity Read ↗

A susceptibility-weighted imaging qualitative score of the motor cortex may be a useful tool for distinguishing clinical phenotypes in amyotrophic lateral sclerosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.