Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

T₂-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 May 2014

Evans Matthew C, Serres Sébastien, Khrapitchev Alexandre A, Stolp Helen B, Anthony Daniel C, Talbot Kevin, Turner Martin R, Sibson Nicola R

Abstract excerpt

Neuroinflammation has been identified as a potential therapeutic target in amyotrophic lateral sclerosis (ALS), but relevant biomarkers are needed. The superoxide dismutase (SOD1)(G93A) transgenic mouse model of ALS offers a unique opportunity to study and potentially manipulate presymptomatic pathology. While T₂-weighted magnetic resonance imaging (MRI) has been shown to be sensitive to pathologic changes at...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Blood-Brain Barrier

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Stem

Share to Microglia

Share to Permeability

Share to Spinal Cord

Share to Superoxide Dismutase-1

Share to Weight Loss

Source

Open in PubMed Open full text

Identifiers

PMID: 24496176
DOI: 10.1038/jcbfm.2014.19
PMCID: PMC4013759

Genes

MTR
SOD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

T₂-weighted MRI detects presymptomatic pathology in the SOD1 mouse model of ALS.PMID 24496176Read ↗

Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Metabolic progression markers of neurodegeneration in the transgenic G93A-SOD1 mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Evolution of the neurochemical profiles in the G93A-SOD1 mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

MRI reveals therapeutical efficacy of stem cells: An experimental study on the SOD1(G93A) animal model.Semantic proximity Read ↗

SOD1-positive aggregate accumulation in the CNS predicts slower disease progression and increased longevity in a mutant SOD1 mouse model of ALSSemantic proximity Read ↗

Characterization of early pathogenesis in the <scp>SOD1</scp> <sup>G93A</sup> mouse model of <scp>ALS</scp> : part I, background and methodsSemantic proximity Read ↗

Diffusion Tensor Imaging Reveals Whole-Brain Microstructural Changes in the P301L Mouse Model of TauopathySemantic proximity Read ↗

The Spatiotemporal Pattern of Degeneration in the Cerebellum of the Wobbler Mouse.Semantic proximity Read ↗

Noninvasive Detection of Presymptomatic and Progressive Neurodegeneration in a Mouse Model of Spinocerebellar Ataxia Type 1Semantic proximity Read ↗

Magnetic resonance microscopy and immunohistochemistry of the CNS of the mutant SOD murine model of ALS reveals widespread neural deficits.Semantic proximity Read ↗

DTI reveals whole-brain microstructural changes in the P301L mouse model of tauopathySemantic proximity Read ↗

Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.