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Article

Differential corticospinal tract degeneration in homozygous 'D90A' SOD-1 ALS and sporadic ALS.

Journal of neurology, neurosurgery, and psychiatry - 1 Aug 2011

Blain C R V, Brunton S, Williams V C, Leemans A, Turner M R, Andersen P M, Catani M, Stanton B R, Ganesalingham J, Jones D K, Williams S C R, Leigh P N, Simmons A

Abstract excerpt

BACKGROUND: The homogeneous genotype and stereotyped phenotype of a unique familial form of amyotrophic lateral sclerosis (ALS) (patients homozygous for aspartate-to-alanine mutations in codon 90 (homD90A) superoxide dismutase 1) provides an ideal model for studying genotype/phenotype interactions and pathological features compared with heterogeneous apparently sporadic ALS. The authors aimed to use diffusion...

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Identifiers

PMID: 21515558
DOI: 10.1136/jnnp.2010.236018
PMCID: PMC3134064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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