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Article

Increased functional connectivity common to symptomatic amyotrophic lateral sclerosis and those at genetic risk.

Journal of neurology, neurosurgery, and psychiatry - 1 Jun 2016

Menke Ricarda A L, Proudfoot Malcolm, Wuu Joanne, Andersen Peter M, Talbot Kevin, Benatar Michael, Turner Martin R

Abstract excerpt

OBJECTIVE: To discern presymptomatic changes in brain structure or function using advanced MRI in carriers of mutations predisposing to amyotrophic lateral sclerosis (ALS). METHODS: T1-weighted, diffusion weighted and resting state functional MRI data were acquired at 3 T for 12 asymptomatic mutation carriers (psALS), 12 age-matched controls and affected patients with ALS. Cortical thickness analysis, voxel-based...

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Identifiers

PMID: 26733601
DOI: 10.1136/jnnp-2015-311945
PMCID: PMC4893149

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