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Article

Multimodal longitudinal study of structural brain involvement in amyotrophic lateral sclerosis.

Neurology - 16 Jun 2020

van der Burgh Hannelore K, Westeneng Henk-Jan, Walhout Renée, van Veenhuijzen Kevin, Tan Harold H G, Meier Jil M, Bakker Leonhard A, Hendrikse Jeroen, van Es Michael A, Veldink Jan H, van den Heuvel Martijn P, van den Berg Leonard H

Abstract excerpt

OBJECTIVE: To understand the progressive nature of amyotrophic lateral sclerosis (ALS) by investigating differential brain patterns of gray and white matter involvement in clinically or genetically defined subgroups of patients using cross-sectional, longitudinal, and multimodal MRI. METHODS: We assessed cortical thickness, subcortical volumes, and white matter connectivity from T1-weighted and diffusion-weighted...

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Identifiers

PMID: 32414878
DOI: 10.1212/WNL.0000000000009498
PMCID: PMC7455328

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