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Article

Implications of structural and functional brain changes in amyotrophic lateral sclerosis.

Expert review of neurotherapeutics - 1 May 2018

Dharmadasa Thanuja, Huynh William, Tsugawa Jun, Shimatani Yoshimitsu, Ma Yan, Kiernan Matthew C

Abstract excerpt

INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes progressive muscle weakness and disability, eventually leading to death. Heterogeneity of disease has become a major barrier to understanding key clinical questions such as prognosis and disease spread, and has disadvantaged clinical trials in search of therapeutic intervention. Patterns of disease have been explored...

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PMID: 29667443
DOI: 10.1080/14737175.2018.1464912

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