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Article

Dissecting APOBEC3G Substrate Specificity by Nucleoside Analog Interference

10 Jan 2009

Abstract excerpt

The apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like (APOBEC) cytidine deaminase genes encode a set of enzymes including APOBEC1 (A1), APOBEC2 (A2), APOBEC4 (A4), and APOBEC3A-H (A3A-H). Although each possesses one or more zinc binding motifs conserved among enzymes catalyzing C-->U conversion, the functions and substrate specificities of these gene products vary considerably. For example,...

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PMID: 19136562
DOI: 10.1074/jbc.m807258200

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