Article
Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity.
Current biology : CB - 26 Jan 2005
Newman Edmund N C, Holmes Rebecca K, Craig Heather M, Klein Kevin C, Lingappa Jaisri R, Malim Michael H, Sheehy Ann M
Abstract excerpt
The antiretroviral activity of the cellular enzyme APOBEC3G has been attributed to the excessive deamination of cytidine (C) to uridine (U) in minus strand reverse transcripts, a process resulting in guanosine (G) to adenosine (A) hypermutation of plus strand DNAs. The HIV-1 Vif protein counteracts APOBEC3G by inducing proteasomal degradation and exclusion from virions through recruitment of a cullin5 ECS E3...
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