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Article

Profiling model T-cell metagenomes with short reads

9 Jan 2009

Abstract excerpt

MOTIVATION: T-cell receptor (TCR) diversity in peripheral blood has not yet been fully profiled with sequence level resolution. Each T-cell clonotype expresses a unique receptor, generated by somatic recombination of TCR genes and the enormous potential for T-cell diversity makes repertoire analysis challenging. We developed a sequencing approach and assembly software (immuno-SSAKE or iSSAKE) for profiling T-cell...

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PMID: 19136549
DOI: 10.1093/bioinformatics/btp010

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