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Article

Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing.

Genome research - 1 Oct 2009

Freeman J Douglas, Warren René L, Webb John R, Nelson Brad H, Holt Robert A

Abstract excerpt

T-cell receptor (TCR) genomic loci undergo somatic V(D)J recombination, plus the addition/subtraction of nontemplated bases at recombination junctions, in order to generate the repertoire of structurally diverse T cells necessary for antigen recognition. TCR beta subunits can be unambiguously identified by their hypervariable CDR3 (Complement Determining Region 3) sequence. This is the site of V(D)J recombination...

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Share to Algorithms
Share to Antibody Diversity
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Genes, T-Cell Receptor beta

Share to Immunoglobulin Variable Region

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to VDJ Recombinases

Source

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Identifiers

PMID: 19541912
DOI: 10.1101/gr.092924.109
PMCID: PMC2765271

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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