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Article

Robust estimates of overall immune-repertoire diversity from high-throughput measurements on samples.

Nature communications - 15 Jun 2016

Kaplinsky Joseph, Arnaout Ramy

Abstract excerpt

The diversity of an organism's B- and T-cell repertoires is both clinically important and a key measure of immunological complexity. However, diversity is hard to estimate by current methods, because of inherent uncertainty in the number of B- and T-cell clones that will be missing from a blood or tissue sample by chance (the missing-species problem), inevitable sampling bias, and experimental noise. To solve...

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Identifiers

PMID: 27302887
DOI: 10.1038/ncomms11881
PMCID: PMC4912625

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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