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Next generation sequencing for TCR repertoire profiling: Platform‐specific features and correction algorithms

19 Jul 2012

Abstract excerpt

The TCR repertoire is a mirror of the human immune system that reflects processes caused by infections, cancer, autoimmunity, and aging. Next generation sequencing (NGS) is becoming a powerful tool for deep TCR profiling; yet, questions abound regarding the methodological approaches for sample preparation and correct data interpretation. Accumulated PCR and sequencing errors along with library preparation...

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PMID: 22806588
DOI: 10.1002/eji.201242517

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